Zeinmersome nanocarriers for drug delivery to the liver

Participant

Hussam Aly Sayed Murad

Entity

Faculty of Medicine, Rabigh Branch

Entity Type

Faculty | كلية

Project Type

Registered Patent | براءة اختراع مسجلة

Technical Readiness Level

TRL 3

Contact

hamurad@kau.edu.sa
541541341

Project Description

Zeinmersome (ZMS), a novel nanocarrier comprising zein, a phospholipid and a PEG-polymer, is formulated to encapsulate a drug of interest. Olmesartan medoxomil (OM); a widely used angiotensin receptor blocker with unique characteristics favouring tissue protection; is encapsulated in the ZMS (OM-ZMS) for oral administration and taken up by the liver where OM diffuses from the ZMS nanocarrier. Free olmesartan concentrations in liver were at least 8 times higher than that measured in plasma. Established fibrosis was reversed in a thioacetamide-induced rat model of human chronic hepatic fibrosis. The OM-ZMS provides a hepatic drug delivery system; that reduces the potential of side effects caused by OM; to treat chronic hepatic fibrosis and associated duodenal changes.

Awards & Recognition

1) Bronze medal, the 50th International Exhibition of Inventions Geneva, 2025.
2) Award from the National Research Council of Thailand at the 50th International Exhibition of Inventions Geneva, 2025.
3) Diploma from the Hong Kong Representative at the 50th International Exhibition of Inventions Geneva, 2025.
4) Certificate of Appreciation, Saudi Ministry of Education, at the 50th International Exhibition of Inventions Geneva, 2025.

Project Resources

Project Images/Documents:

Google Drive
https://drive.google.com/file/d/1hbB70wCWrNGSjLm9ONfJy2dKfA58EHgF/view?usp=sharing

No project resources or links available for this project.

Exhibition Information

Will Display Prototype:

No

Presentation Methods:

Printed Poster | ملصق مطبوع

Additional Notes:

This Patent (US10905651B1) was the basis for a second patent which is a novel "Method of treating chronic hepatic fibrosis comprising administration of zeinmersome nanocarriers" (Patent No. US11013689B1)